Cell Signaling Tips for Healthy Skin: Insights from UT Southwestern Researchers - Health

UT Southwestern Researchers Investigate Cell Signaling in Skin Cells

UT Southwestern researchers have delved into the intricate world of cell signaling within skin cells , particularly focusing on keratin intermediate filaments that play a crucial role in Wound Healing . The study , led by Benjamin Nanes , M.D. , Ph.D. , Assistant Professor of Dermatology , and published in Developmental Cell , sheds light on how these proteins not only provide mechanical strength to human skin but also orchestrate molecular signals that govern skin cell activity . The findings of this research have the potential to revolutionize the treatment of various skin diseases , such as ulcers and skin cancer.

 Its never been clear why skin needs this many proteins and their complicated expression pattern just to provide mechanical strength . People have been very interested in what else these proteins might do , and were finally starting to get answers , said first author Benjamin Nanes , M.D. , Ph . D.

The Role of Keratin Intermediate Filaments in Skin Cell Activity

Keratin intermediate filaments ( KIFs ) are essential components that contribute to the mechanical strength of the skin . These rope - like proteins traverse the interior of skin cells , forming connections between cells and ensuring structural integrity . The intricate family of 54 KIF members is produced by cells in varying combinations depending on the circumstances . For instance , during wound healing , specific KIFs like K6A , K6B , K6C , K16 , and K17 are upregulated in higher proportions than other KIFs . Despite the changing composition of KIFs , the overall strength of the skin remains constant , prompting researchers to explore the underlying mechanisms that regulate skin cell behavior.

Genetic Engineering Reveals Insights into Skin Cell Behavior

To unravel the mysteries surrounding KIFs and their impact on skin cell activity , Benjamin Nanes and his team genetically engineered skin cells to overexpress different KIFs associated with either wound healing or intact skin . By growing these modified cells into skin organoids , researchers observed distinct behaviors in cells with higher expression of wound - associated KIFs , such as enhanced migration capabilities . Further investigations revealed that the abundance of K6A influenced the activation of myosin motors , which are responsible for cellular movement . The findings suggest that KIFs serve as platforms for signaling molecules to interact , thereby regulating various cellular functions.

The study paves the way for future research to explore additional molecular switches controlled by KIFs and their implications for skin cell behavior . Dr. Nanes and his colleagues are dedicated to uncovering the intricate mechanisms that govern cell signaling in skin cells , with the ultimate goal of developing novel therapeutic strategies for skin diseases.