Time: 2024-08-05
A recent clinical trial conducted at Oregon Health & Science University ( OHSU ) has shown promising results regarding the benefits of Fish oil supplements for older adults with a genetic predisposition to Alzheimer 's disease . The study , published in the journal JAMA Network Open , focused on the impact of fish oil supplements on brain function in individuals with memory problems . While no statistically significant benefit was found for all older adults , participants carrying the APOE4 gene associated with Alzheimer 's disease demonstrated a reduction in nerve cell breakdown in the brain.
The research involved 102 participants aged 75 and older with low levels of omega-3 fatty acids in their blood . Magnetic resonance imaging ( MRI ) scans were conducted at the beginning and end of the three - year study to assess changes in white matter lesions in the brain , which can contribute to the risk of developing dementia later in life . Half of the participants took omega-3 fish oil supplements daily , while the other half received a soybean - based placebo . The study found a slight reduction in the progression of white matter lesions in both groups , but a more significant decrease was observed in APOE4 carriers who received fish oil supplements.
According to the study 's senior co - author , Lynne Shinto , N.D. , M.P.H. , fish oil supplements may be beneficial for individuals with the APOE4 gene , indicating a higher risk of Alzheimer 's disease . While the results highlight the potential for personalized nutritional interventions based on genetic predisposition , further research is needed to fully understand the implications and establish definitive guidelines . It is crucial to continue exploring other lifestyle and dietary factors that can contribute to brain health in older adults.
Experts caution against generalizing the use of fish oil supplements for all older adults and emphasize the importance of consulting medical professionals before taking any dietary supplements . While fish oils are generally safe , individuals with specific genetic factors , such as APOE4 carriers , may have age- and dose - dependent responses to supplementation . Increasing omega-3 intake through diet , such as consuming small cold - water fish , is recommended as a safer alternative to supplement use . Further clinical trials are necessary to validate the findings of this study and provide clearer guidance on the role of fish oil in reducing Alzheimer 's risk.
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