Time: 2024-07-21
Researchers at the University of Arizona Health Sciences have found a new way to enhance the effectiveness of opioids in Pain management by inhibiting a specific Heat shock protein 90 isoform . The conventional use of opioids for chronic pain relief often leads to various negative side effects such as addiction and respiratory depression . The study focuses on reducing these adverse effects while maintaining pain relief effectiveness through spinal inhibition of the Hsp90 isoform.
In their research , the team discovered that inhibiting Hsp90 in the spinal cord amplifies the pain - relieving effects of morphine . By using selective inhibitors to target individual isoforms of Hsp90 , they were able to enhance the potency of pain relief provided by morphine while reducing tolerance levels . The goal is to develop a new drug that can offer the same pain relief benefits with fewer negative side effects , benefitting millions of individuals living with chronic pain.
Meanwhile , researchers at Mainz University have identified a natural compound called aniquinazolin B that stimulates opioid receptors and has the potential to serve as a safe alternative to opioids for pain management . The compound , isolated from the marine fungus Aspergillus nidulans , could provide long - term relief without the risk of addiction and severe side effects associated with traditional opioids.
The research team at Mainz University utilized a database of natural substances to identify aniquinazolin B , which showed promising results in binding to opioid receptors and demonstrating pharmaceutical drug properties . Through extensive research and testing , the compound was found to activate opioid receptors and influence their functioning similarly to opioids but with fewer undesirable reactions.
The findings from both studies offer new insights into pain management and the potential for developing safer alternatives to traditional opioids . By targeting specific proteins like Hsp90 isoforms and exploring natural compounds , researchers are paving the way for innovative therapies that could revolutionize pain relief treatments . The development of novel drugs with enhanced pain - relieving properties and fewer side effects could significantly improve the quality of life for individuals suffering from chronic pain . Further research and clinical trials are needed to validate these findings and bring these innovative solutions to patients worldwide.
Business
