Understanding the Role of EPHA2 in Stem Cell Therapies to Prevent Tumor Formation

Pluripotent stem cells (PSCs) hold tremendous potential for regenerative medicine, but the risk of tumor formation has been a significant obstacle. Scientists are making strides in addressing this challenge by identifying key factors that could impact the success of stem cell therapies. A recent study led by Atsushi Intoh and Akira Kurisaki has shed light on the role of the membrane protein EPHA2 in preventing tumorigenesis. By targeting EPHA2-expressing stem cells, researchers were able to significantly reduce the formation of tumors in transplant recipients. These findings offer promising insights that could enhance the safety and efficacy of PSC-based treatments, bringing us closer to a future where damaged organs can be restored and degenerative conditions can be overcome. The study was published in Stem Cells Translational Medicine in 2024.