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Health

Time: 2024-12-15

Enhance Cancer Treatment with Ketogenic Diet Tips

Enhance Cancer Treatment with Ketogenic Diet Tips
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revolutionize cancer treatment with dietary Supplements

A Holocene survey from the Perelman School of Medicine at the University of Pennsylvania and Penn Medicines Abramson Cancer Center has bespeak a new approach to boost Chimeric antigen receptor ( CAR ) thymine cell function through a simple dietary addendum. The survey show at the 66th American Society of Hematology ( ASH ) Annual Meeting and Exposition showcased the potential of enhance CAR T cell therapy effectiveness through dietary interventions.

Enhance Cancer Treatment with Ketogenic Diet Tips

enhance CAR thymine cell function with a Ketogenic Diet

research_worker test assorted diet, include ketogenic, high-fiber, high-fat, high-protein, and high cholesterol, on CAR T cell in a mouse model of diffuse large B-cell lymphoma. The consequence show that a Ketogenic diet significantly better tumor control and survival compare to other diet. The key mediator of this consequence was found to be beta-hydroxybutyrate ( BHB ), a metabolite produce in response to a ketogenic diet. This survey physique on previous research that found BHB suppress the growth of colorectal tumor in lab experiments.

translational survey and Human Evidence

The research team further test a BHB addendum unite with CAR T cell therapy in homo cancer model and found complete annihilation of cancer in most case, with increase CAR T cell expansion and activation. In homo survey, higher BHB degree were associate with better CAR T cell expansion in patient who receive CAR T cell therapy. Additionally, a small-scale test with healthy volunteer show that oral BHB supplement enhance T cell respiratory capacity and energy production.

potential impact and Future Directions

The findings from the survey propose that a ketogenic diet or BHB supplement can significantly enhance CAR T cell therapy, potentially better result in get_worse or furnace_lining cancer. A clinical test at Penn Medicines Abramson Cancer Center is currently afoot to measure BHB supplement in patient with not-Hodgkin lymphoma receive CAR T cell therapy. The research_worker purpose to research the feasibility and effects of BHB supplement on patient' immune system and investigate the function of the microbiome in enhance CAR T cell function. If successful, this approach could pave the manner for integrate dietary scheme into cancer immunotherapy protocols.

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