Plasmodium Falciparum Cure: Tips for Healthy Wellness with New Medication - Health

In 2022, nearly 619,000 global death due to malaria were cause by Plasmodium falciparum, the most deadly, prevailing, and deadly homo malaria parasite. For decade, the parasite resistance to all antimalarial drug has present a large challenge for research_worker working to stop the spread of the disease.

A team light-emitting_diode by scientist at UC Riverside, UC Irvine, and Yale School of Medicine has now plan a new drug against malaria and identify its mechanism of action. The research_worker found the drug, name MED6-189, is effective against drug-medium and drug-immune P. falciparum strain in vitro as well as in a humanize mouse model ( the mouse were engineer to rich_person homo blood).

 break of the apicoplast and vesicular traffic block the parasite development and thus extinguish infection in red blood cell and in our humanize mouse model of P. falciparum malaria, state Karine Le Roch, a professor of molecular, cell and system biology at UCR and the document senior author.

research_worker have detect a new chemical compound, MED6-189, that is a strong inhibitor of parasite that are immune to commonly use antimalarial drug. The high authority, excellent remedy profile, and alone manner of action of MED6-189 brand it an excellent addition to the antimalarial drug grapevine, the research_worker said.

Despite development in prevent and treat malaria, the disease remains a lead populace health menace worldwide. In 2022, the disease cause an estimate 247 million clinical case and 619,000 death, harmonize to the World Health Organizations World Malaria Report 2023.

One of the large challenge in control malaria is the resistance of the parasite to commonly use antimalarial drug, state Choukri Ben Mamoun, PhD, professor of medicine ( infectious disease ), microbial pathogenesis, and pathology at Yale School of Medicine.

 This survey represent a true system biology approach to antimalarial drug discovery and is an excellent example of a collaborative team-science attempt integrate expertness across multiple institution and discipline, state Amy Bei, PhD, associate professor of epidemiology ( microbial disease ) at the Yale School of Public Health and carbon_monoxide-writer of the study.

The research_worker detect that in Plasmodium falciparum, the pathogen responsible for the most severe form of homo malaria, MED6-189 could suppress both the parasite asexual development in the blood and its ability to undergo sexual differentiation, a critical measure in malaria transmission.

Both Bei and Ben Mamoun stress the pressing need to continue optimize this class of compound and identify novel antimalarials.

Malaria is here to stay, and with widespread resistance, we need to articulation attempt to develop better remedy scheme. This compound could function on its own like a combination therapy, which typically use multiple drug to target a single organism and lower_berth the opportunity of resistance, much like we do with HIV and other diseases.