Time: 2024-09-18
In a Holocene clinical test by the ECOG - ACRIN Cancer Research Group , neoadjuvant chemotherapy has show significant benefit for patient with advance squamous cell - type cancer of the nose or fistula . The test consequence were foreground at the ESMO Congress 2024 in Barcelona , Spain . surgery is often necessity for these patient , but it semen with a high physical cost . However , patient who receive chemotherapy before surgery have a 50 % opportunity of continue critical structure , such as the eye and the base of the skull bone , compare to only a 15 % opportunity for those who undergo surgery as the standard treatment.
lead research_worker Nabil F. Saba stress the importance of chemotherapy before surgery in better organ preservation for patient with nasal_consonant and paranasal fistula squamous cell carcinoma . The test aim to enroll 82 patient , but only 23 were measure due to decelerate accumulation . Despite this , the consequence were promise , screening that neoadjuvant chemotherapy could enhance the opportunity of structural preservation in these patient . The rare nature of this disease brand it challenge to behavior test , but the EA3163 test supply a reliable platform for a more aim comparison of treatment approaches.
The survey found that patient who receive chemotherapy before surgery have a significantly higher opportunity of continue critical structure compare to those who undergo surgery alone . The consequence support the use of neoadjuvant chemotherapy as an effective intervention to better organ preservation in patient with Head and neck cancer . Dr. Saba and colleague believe that future test should research modify chemotherapy choice or add immunotherapy to further enhance organ preservation and better survival rates for these patients.
chemotherapy prior to surgery has been found to reduce the sum of convention tissue that need to be remove in patient with advance nasal_consonant and paranasal fistula squamous cell carcinoma . This rare disease affect about 2,000 patient in the US each year , primarily aged person . patient with tumor near critical structure like the orbit and the base of the skull bone may face significant challenge during surgery and postoperative care . By supply chemotherapy before surgery , the survey aim to better organ preservation and reduce the enfeeble effects of surgery and radiation for these patients.
The research_worker hope that their findings will lend to increase the current 5 - year survival rate , which is below 50 % for patient with this type of cancer . The survey participant will continue to be monitor for 2 - year overall survival to buttocks the hanker - term benefit of neoadjuvant chemotherapy in better organ preservation and patient outcomes.
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