Time: 2024-09-05
prostate_gland cancer is a prevailing cancer among work_force , and the use of PARP inhibitor has show promise consequence in the treatment of this disease .
At the Holocene eighth Annual School of Nursing Oncology , Michael Lai , ARNP , from the Fred Hutchinson Cancer Center , show on the optimize use of PARP inhibitor in treat patient with prostate_gland cancer . Lai explain that PARP inhibitor work by suppress the PARP protein , an enzyme involve in single - strand deoxyribonucleic_acid repair . By suppress PARP , double - strand deoxyribonucleic_acid interruption can happen , lead to cancer cell death . Some PARP inhibitor include olaparib ( Lynparza ) , rucaparib ( Rubraca ) , and niraparib ( Zejula).
In convention cell , the homologous recombination repair procedure is crucial for address double - strand deoxyribonucleic_acid interruption and acting deoxyribonucleic_acid damage repair . However , cell with mutant in homologous recombination repair , such as BRCA1 or BRCA2 , are vulnerable . exploitation a PARP inhibitor in these cell can close down the single - strand deoxyribonucleic_acid repair nerve_pathway , lead to cancer cell death . The target approach of PARP inhibitor in prostate_gland cancer cell with particular deoxyribonucleic_acid repair mutant purpose to better control the disease.
The use of PARP inhibitor like olaparib in the treatment of prostate_gland cancer represent a significant promotion in preciseness medicine . By target particular deoxyribonucleic_acid repair mutant , these inhibitor clasp great promise for better patient result and survival rates . foster research and clinical test are necessitate to fully understand the potential of PARP inhibitor in the personalize treatment of prostate_gland cancer . As the field of oncology continue to evolve , the optimization of PARP inhibitor offer new hope for patient battle this challenge disease.