Time: 2024-09-04
scientist have make significant advancement in understanding how the brain procedure prediction mistake , involve the neopallium and thalamus working together to detect discrepancy between expectation and world . These prediction mistake are crucial for learning and updating prediction in response to unexpected event . The research conduct at the Sainsbury Wellcome Centre at UCL exploitation mouse in a virtual world environment shed light on the nervous mechanism responsible for implement prediction mistake signal in the brain.
One of the key findings of the survey was the synergistic interaction between VIP nerve_cell in the neopallium and the pulvinar nucleus in the thalamus . The research_worker detect that these two brain region act together to magnify unexpected centripetal input_signal , enhance the brain 's response to deviation from prediction . This cooperative interaction play a crucial function in intercede centripetal prediction mistake signal in the ocular cerebral_cortex , supply valuable penetration into how the brain procedure unexpected events.
The survey uncover that when particular inhibitory interneurons in the neopallium , know as VIP nerve_cell , are inactive , thalamic input_signal suppress cortical activity . However , when these nerve_cell are active_agent , thalamic input_signal enhance cortical response . The research_worker use optogenetics to pinpoint the importance of these two group of nerve_cell in generate prediction mistake signal , highlight the intricate nervous circuit responsible for processing unexpected stimulation in the brain.
understanding how the brain generate prediction mistake signal is not only crucial for learning and adapt to new information but also hour_angle deduction for neurological disorder such as autism spectrum disorder ( ASDs ) and schizophrenia spectrum disorder ( SSDs ) . The imbalance in the prediction mistake system has been propose as a potential explanation for the symptom detect in person with ASDs and SSDs.
In ASDs , difference in mistake signal could lead to centripetal hypersensitivity , where overly precise prediction consequence in excessive prediction mistake signal . On the other hand , SSDs may involve incorrect internal model of the universe due to decrease prediction mistake signal , lead to incorrect centripetal percept . By further investigation the underlie mechanism of prediction mistake , research_worker purpose to supply a foundational understanding of how the brain effectively perceive the universe and how these findings could be use to better result for person with neurological disorders.
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