Time: 2024-08-31
cell surface receptor such as FZD 7 play a crucial function in how cell communicate and function . These receptor are responsible for trip event inside the cell that control growth , differentiation , and motion . harmonize to the survey 's writer Gunnar Schulte , a professor at the Karolinska Institutet , receptor activation is a key measure in signal transduction processes.
research_worker have use cryo - electron microscopy to addition a detail image of the structure of FZD 7 at a high resolution of 1.9 angstrom . This discovery let for a better understanding of the activation mechanism of the receptor . The presence of cholesterol has been found to facilitate the interaction between FZD 7 and another protein , tousle , enable the transmission of signal within the cell.
The discovery of how FZD 7 function not only enhance cognition of receptor mechanism but also open up possibility for target therapy . In conditions such as colorectal cancer , where FZD 7 is hyperactive , understanding the activation procedure in detail supply opportunity to develop treatment that can block this overactivity . This research set the phase for foster survey and pharmacological analysis aim at produce new drug for such diseases.
cholesterol 's function in intercede the interaction between FZD 7 and Dishevelled highlight the importance of lipid molecule in cellular signal nerve_pathway . By clarify the structural footing of FZD 7 activation and regulation , the survey lend to a deep understanding of how cell react to external signal and regulate their internal functions.
The survey , fund by assorted organization include the Swedish Research Council and the Swedish Cancer Society , shed light on the intricate mechanism involve in cell signal . With the publication of their findings in Nature Communications , the research_worker have supply a foundation for future probe that purpose to translate this cognition into novel remedy intervention for disease involve dysregulated cell signal pathways.
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