Time: 2024-08-02
In recent research conducted at the University of Texas at Austin Department of Chemistry , scientists have made significant progress in developing a method to deliver aptamer - based fluorescent sensors across the blood - brain barrier ( BBB ) in mouse models of Alzheimer 's disease . The team , led by Yi Lu , PhD , has found a way to use brain - cell derived exosomes to transport ATP - responsive aptamer sensors to the brain , enabling improved brain imaging . These sensors play a crucial role in detecting neurotransmitters and monitoring brain health , particularly in neurodegenerative disorders like Alzheimer 's disease.
The study published in ACS Central Science showcases the potential of these novel sensors in identifying variations in ATP levels in different regions of the brain affected by Alzheimer 's disease . By encapsulating the ATP aptamer sensor in exosomes , which are microscopic vesicles derived from brain cells , the researchers were able to achieve a more efficient delivery system that outperformed traditional synthetic delivery methods . This innovative approach opens up new possibilities for non - invasive live brain imaging and could pave the way for the development of sensors targeting a range of essential neurotransmitters.
The findings of the study shed light on the fundamental role of metabolites like ATP in neurobiology . The researchers noted that a decline in neurotransmitter levels , particularly ATP , could serve as an early indicator of Alzheimer 's disease . By utilizing fluorescent sensors based on DNA aptamers , the team was able to pinpoint the specific brain regions with low ATP levels associated with the disease . This spatial resolution in live tissue provides valuable insights into the pathology of Alzheimer 's disease and highlights the importance of regional differences in disease progression.
The successful delivery of ATP - reactive sensors through exosomes in mouse models of Alzheimer 's disease marks a significant milestone in the field of neuroimaging . The researchers are optimistic about the potential of this technology to revolutionize the diagnosis and treatment of Alzheimer 's disease . With further refinement and expansion to include sensors for other metabolites , this method holds promise for advancing our understanding of brain health and neurodegenerative diseases . The study was supported by various funding sources , including the National Science Foundation and the US National Institutes of Health , underscoring the importance of continued research in this critical area of Medical imaging and neuroimaging.
Business
