Time: 2024-06-30
Recent research conducted by Johns Hopkins University and the National Institute on Aging at the National Institutes of Health has shown that intermittent fasting and a standard healthy diet can enhance brain function in obese adults with insulin resistance. The study involved 40 older adults with obesity and insulin resistance who were randomly assigned to follow either an intermittent fasting regimen or a standard healthy diet recommended by the U.S. Department of Agriculture (USDA). The findings provide valuable insights into the potential brain health benefits of both dietary approaches. Insulin resistance, a common condition in people with obesity, is associated with a higher risk of cognitive impairments and Alzheimer's disease.
To isolate neuron-derived extracellular vesicles from blood and study the effects of the diets on brain function biomarkers, participants were recruited between June 2015 and December 2022. The average age of participants was 63, and they were predominantly white, with 24 men and 16 women. Both diet plans resulted in positive effects on reducing insulin resistance markers, improving BrainAGE, and lowering glucose concentration in the brain. The study found that intermittent fasting had a more significant impact on executive function and memory compared to the standard healthy living diet.
A few study participants experienced minor side effects such as constipation, loose stools, and occasional headaches. The researchers observed increased levels of a neurofilament protein, primarily in the intermittent fasting group, indicating potential neuroplasticity in neurons. However, the implications of this finding on brain health remain unclear. It is important to note that intermittent fasting may not be suitable for everyone, especially individuals with type 1 diabetes or eating disorders. Careful planning with a healthcare practitioner is recommended for those considering intermittent fasting.
In conclusion, the study highlights the positive effects of intermittent fasting and a healthy diet on brain function in obese adults with insulin resistance. The research provides valuable insights into the benefits of dietary interventions in reducing the risk of cognitive impairments and metabolic disorders associated with insulin resistance. Further studies are needed to explore the long-term effects of intermittent fasting on brain health and to clarify the mechanisms underlying these positive outcomes.
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